| S.No. | Title of Project and Sanction Letter No | Sponsor / Funding Agency | Sanctioned Amount (Rs. in Lakhs) | Tenure / Duration | Supervisor / Principal Investigator / Co-Supervisor | Number of Manpower / Research Fellows | Brief Objective |
|---|---|---|---|---|---|---|---|
| In-Progress | |||||||
| 1. | Design and Synthesis of New Amphiphatic Cyclopeptides, Study of their Antimicrobial Activity and Antibiotic Synergy SUR/2022/004226 | DST-SERB | 2992000 | 3 years | Dr. Deepak B. Salunke / Dr. Rachna Singh Department of Microbiotechnology Panjab University Chandigarh | 1 | To synthesize a library of novel bile acid based cyclopeptides comprising valine, lysine, glutamine, glutamate and serine. • In vitro antimicrobial study with gram positive (S. aureus ATC 29213), gram negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa) and anti-fungal strain (Candida albicans). • Fluorometric assessment of selective permeabilization of microbial membranes will be investigated using 1-N phenylnaphthylamine and/or 3,3-diethylthiadicarbocyanine iodide probes to see the membrane-permeabilization behavior of the synthesized compounds. • Synergistic effect of synthesized analogs in combination with other antibiotics (cefotaxime, amikacin, ciprofloxacin, and vancomycin). • To determine the activity of the compounds against the drug-resistant clinical isolates of S. aureus 1704, E. coli 4052, and C. auris. |
| 2. | Project titled "Development of NIR Emitting Peptide Conjugated Metallic Nanoclusters for Effective Photothermal Therapy CRG/2022/006638 | DST-SERB | 3692000 | 3 years | Dr. Rohit Kumar Sharma / Dr. Aravind Rengan IIT Hyderabad Dr. Nishima P.U. | 1 | 1: Synthesis and characterization of metallic nanoclusters (MNCs) as photothermal agents (PTA) in NIR domain Objective 2: Synthesis and characterization of tumor targeting peptides (TTPs) to enhance the selectivity of photothermal agents (PTAs) Objective 3: Conjugation of highly specific tumor targeting peptides (TTPs) to PTAs as an efficient and selective system for improved PTT |
| 3. | Development of new lipidated small molecules as potential vaccine adjuvants STRE/RP/147/e-2873/22-23/Sanc/09/202 | DST-UT | 200000 | 1 year | Dr. Deepak B. Salunke / Dr. Sandip Pawar UIPS PU Chandigarh | 0 | The project will comprise of following segments: 1. To optimise the synthesis of hybrid structures comprising TLR7/8 agonistic imidazoquinolines linked to TLR2 agonistic lipopeptides: Two hybrid compounds will be synthesized as described in the work plan. 2. Purification and characterization of the synthesized hybrid molecules. 3. Screening of the TLR7/8 and TLR2 agonistic activity as well as cytotoxicity of the synthesized hybrid molecules. |
| 4. | Development of peptide-based infection imaging agents 58/14/14/2022-BRNS/37060 | BRNS | 4087600 | 3 years | Dr. Rohit Kumar Sharma / Dr. Archana Mukherjee BARC Mumbai | 1 | 1. To Synthesize novel peptides for development of infection imaging agents 2. To Synthesize novel AMP conjugates for radio-labelling to be used for in vitro evaluation of new infection imaging agents. |
| 5. | Fabrication of polymer dots from multicomponent tandem polymer receptors for sensing applications SPG/2021/002995-G | DST-SERB | 2884200 | 3 years | Prof. Navneet Kaur / NA | 0 | Development and characterization of variedly substituted monomeric and polymeric receptors based on Pyrimidine derivatives by multicomponent single pot reactions. Evaluation and sensing activity of developed sensor systems for detection of biologically important analytes. |
| 6. | Fabrication of ultrasensitive smart kit for detection of toxic lead traces in water, food and soil samples 306/RUSA/2022 | RUSA | 500000 | 2 years | Dr. Rohit Kumar Sharma / Prof. N. Sujatha IIT Madras | 1 | 1: Optimizations for the sensitive, selective and rapid detection of lead ions by developing aptasensor using cationic peptide and plasmonic gold nanoparticles Objective 2: Fabrication of portable detction kit using the developed aptasensor for detection of Pb2+ ions in various water, food and soil samples Objective 3. Validation of Pb2+ ions in real samples using the designed kit and quantitative analysis using electronic/smartphone |
| 7. | Biocompatible metallosomes: fabrication, characterization and their interactional behavior with biomolecules CRS/2021-22/03/543 | UGC-DAE CSR | 243240 | 3 years | Dr. Gurpreet Kaur Department of Chemistry PU / Dr. V.K. Aswal Solid State Physics Division BARC Mumbai | 0 | (i) To synthesize metallosurfactants based metallosomes with varying metal ions and surfactants. (ii) Systematic characterization of prepared metallosomes. (iii) To explore these metallosomes for encapsulation of dyes. (iv) To study the interaction of metallosomes with biomolecules i.e. Protein, DNA, RNA etc. |
| 8. | Nanodelivery and evaluation of adjuvant effect of synthetic TLR4 and TLR7 agonists combination in chicken CRG/2021/005467 | DST-SERB | 6218400 | 3 years | Dr. Saravanan Ramakrishnan Senior Scientist IVRI Bareilly / Dr. Deepak B. Salunke | 1 | The aim of project is to design and synthesize novel TLR4 and TLR7 agonists and adjuvantic effect these agonists will be explored for malaria and influenza. The delivery systems such as Lipid carriers and Nano emulsion will be fabricated to encapsulate these agonists. |
| 9. | COPPER PSEUDOATRANES: SYNTHESIS OF MONO- AND BIMETALLIC CAGES WITH RIGID AND ASYMMETRIC SKELETONS FOR THEIR POTENTIAL APPLICATIONS 013075/21/EMRII | CSIR (HRDG) | 1400000 | 3 years | Dr. Varinder Kaur / Dr. Raghubir Singh | 0 | 1. To synthesize tripodal ligands capable of binding single and multiple metal ions. 2. To synthesize homometallic and heterobimetallic [4.4.3.01,5]tridecane and [4.4.4.01,6]tetradecane cages of copper in pure form. 3. To investigate the structural aspects of the synthesized complexes. 4. To investigate the spectroscopic aspects of the complexes. 5. To apply the synthesized complexes in sensing or catalysis applications. |
| 10. | SYNTHESIS OF MONO AND BIMETALLIC PSEUDOSTANNATRANE CAGES WITH RIGID AND ASYMMETRIC SKELETONS FOR THEIR POTENTIAL APPLICATIONS SPG/2021/000455 | SERB-POWER, India | 2914164 | 3 years | Dr. Varinder Kaur / Dr. Raghubir Singh | 1 | 1. To synthesize and characterize polydentate tripodal ligating systems 2. To synthesize and characterize mono- and heterobimetallic pseudostannatranes. 3. To investigate the spectroscopic and structural features of pseudostannatranes. 4. To investigate the potential applications of pseudostannatranes. |
| 11. | Novel and pliable anthraquinone derivatives for chemo sensing applications 02/0446/21/EMR-II | CSIR, New Delhi | 1400000 | 3 years | Dr. Navneet Kaur / | 0 | To synthesize and characterize tailor made anthraquinone based sensors for their chemo sensing applications. |
| 12. | INVESTIGATION OF GLUTAMINE CONJUGATED ORGANOTIN COMPOUNDS AS CHEMO-THERAPEUTIC AGENTS AND THEIR EVALUATION IN COLON CANCER MODEL SYSTEMS 27/0370/20/EMR-II | CSIR-HRDG | 1500000 | 3 years | Dr. Navneet Agnihotri / Dr. Varinder Kaur | 0 | 1. Synthesis and characterisation of glutamine-based novel organotin derivatives with varying hydrocarbyl groups 2. Selection of potent organotin compounds based on their DNA binding ability 3. Biological characterisation of selected organotin compounds; (i) In vitro studies using colon cancer cell lines (ii) In vivo studies in an animal model of colon carcinoma |
| 13. | Anti-leukemia Peptide Conjugated Quantum dots based targeted formulations as new-age theranostics SPARC/2018-2019/33/SL/IN/ | SPARC-MHRD | 3829986 | 4 years | Dr. Rohit Kumar Sharma / Prof. Hironobo Hojo Prof. Rahul Jain Prof. Toshifumi Takao | 0 | Anti-leukemia Peptide Conjugated Quantum dots based targeted formulations as new-age theranostics |
| 14. | Development of Synthetic TLR2, TLR7/8 and Mincle Agonists for Use as Part of a Combination Adjuvant in Tuberculosis Vaccines SPARC/2018-2019/P386/SL | SPARC-MHRD | 4440000 | 5 years | Dr. Deepak B. Salunke / | 1 | The specific aims of this proposal are: 1. To use available Structure Activity Relationship (SAR) information together with in silico high throughput screening to identify and design novel TLR2, TLR7/8 and Mincle ligands 2. To design methods to chemically synthesize these novel agonists and their self-conjugation with antigen as well as with the AdVax adjuvant and test the specificity of these ligands using TLR2, TLR7/8 and Mincle expressing reporter cell lines 3. To test the capacity of these agonists alone or in combination in murine models to enhance protection of a TB vaccine platform against M. tb infection. |
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